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Abscess

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This article is about the medical condition. For the death metal band, see Abscess (band).
Abscess
Other namesLatin: Abscessus
Five-day-old inflamed epidermal inclusion cyst. The black spot is a keratin plug which connects with the underlying cyst.
SpecialtyGeneral surgery, infectious disease, dermatology
SymptomsRedness, pain, swelling[1]
Usual onsetRapid
CausesBacterial infection (often MRSA)[1]
Risk factorsIntravenous drug use[2]
Diagnostic methodUltrasound, CT scan[1][3]
Differential diagnosisCellulitis, sebaceous cyst, necrotising fasciitis[3]
TreatmentIncision and drainage, Antibiotics[4]
Frequency~1% per year (United States)[5]

An abscess is a collection of pus that has built up within the tissue of the body.[1] Signs and symptoms of abscesses include redness, pain, warmth, and swelling.[1] The swelling may feel fluid-filled when pressed.[1] The area of redness often extends beyond the swelling.[6] Carbuncles and boils are types of abscess that often involve hair follicles, with carbuncles being larger.[7] A cyst is related to an abscess, but it contains a material other than pus, and a cyst has a clearly defined wall. Abscesses can also form internally on internal organs and after surgery.

They are usually caused by a bacterial infection.[8] Often many different types of bacteria are involved in a single infection.[6] In many areas of the world, the most common bacteria present is methicillin-resistant Staphylococcus aureus.[1] Rarely, parasites can cause abscesses; this is more common in the developing world.[3] Diagnosis of a skin abscess is usually made based on what it looks like and is confirmed by cutting it open.[1] Ultrasound imaging may be useful in cases in which the diagnosis is not clear.[1] In abscesses around the anus, computer tomography (CT) may be important to look for deeper infection.[3]

Standard treatment for most skin or soft tissue abscesses is cutting it open and drainage.[4] There appears to be some benefit from also using antibiotics.[9] A small amount of evidence supports not packing the cavity that remains with gauze after drainage.[1] Closing this cavity right after draining it rather than leaving it open may speed healing without increasing the risk of the abscess returning.[10] Sucking out the pus with a needle is often not sufficient.[1]

Skin abscesses are common and have become more common in recent years.[1] Risk factors include intravenous drug use, with rates reported as high as 65% among users.[2] In 2005, 3.2 million people went to American emergency departments for abscesses.[5] In Australia, around 13,000 people were hospitalized in 2008 with the condition.[11]

Signs and symptoms

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An abscess

Abscesses may occur in any kind of tissue but most frequently within the skin surface (where they may be superficial pustules known as boils or deep skin abscesses), in the lungs, brain, teeth, kidneys, and tonsils. Major complications may include spreading of the abscess material to adjacent or remote tissues, and extensive regional tissue death (gangrene).[12]

A naturally drained abscess

The main symptoms and signs of a skin abscess are redness, heat, swelling, pain, and loss of function. There may also be high temperature (fever) and chills.[13] If superficial, abscesses may be fluctuant when palpated; this wave-like motion is caused by movement of the pus inside the abscess.[14]

An internal abscess is more difficult to identify and depend on the location of the abscess and the type of infection. General signs include pain in the affected area, a high temperature, and generally feeling unwell.[15] Internal abscesses rarely heal themselves, so prompt medical attention is indicated if such an abscess is suspected. An abscess can potentially be fatal depending on where it is located.[16][17]

Causes

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Risk factors for abscess formation include intravenous drug use.[18] Another possible risk factor is a prior history of disc herniation or other spinal abnormality,[19] though this has not been proven.

Abscesses are caused by bacterial infection, parasites, or foreign substances. Bacterial infection is the most common cause, particularly Staphylococcus aureus. The more invasive methicillin-resistant Staphylococcus aureus (MRSA) may also be a source of infection, though is much rarer.[20] Among spinal subdural abscesses, methicillin-sensitive Staphylococcus aureus is the most common organism involved.[19]

Rarely parasites can cause abscesses and this is more common in the developing world.[3] Specific parasites known to do this include dracunculiasis and myiasis.[3]

Anorectal abscess

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Main article: Anorectal abscess

Anorectal abscesses can be caused by non-specific obstruction and ensuing infection of the glandular crypts inside of the anus or rectum. Other causes include cancer, trauma, or inflammatory bowel diseases. [21]

Incisional abscess

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An incisional abscess is one that develops as a complication secondary to a surgical incision. It presents as redness and warmth at the margins of the incision with purulent drainage from it.[22] If the diagnosis is uncertain, the wound should be aspirated with a needle, with aspiration of pus confirming the diagnosis and availing for Gram stain and bacterial culture.[22]

Internal abscess

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Abscesses can form inside the body. The cause can be from trauma, surgery, an infection, or a pre-existing condition.[15]

Pathophysiology

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An abscess is a defensive reaction of the tissue to prevent the spread of infectious materials to other parts of the body.[23][24]

Organisms or foreign materials destroy the local cells, which results in the release of cytokines. The cytokines trigger an inflammatory response, which draws large numbers of white blood cells to the area and increases the regional blood flow.[24]

The final structure of the abscess is an abscess wall, or capsule, that is formed by the adjacent healthy cells in an attempt to keep the pus from infecting neighboring structures. However, such encapsulation tends to prevent immune cells from attacking bacteria in the pus, or from reaching the causative organism or foreign object.[24]

Diagnosis

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Ultrasound showing dark (hypoechoic) area involving skin and subcutaneous tissue with moving internal debris in keeping with abscess[25]
Ultrasound image showing an abscess, appearing as a mushroom-shaped dark (hypoechoic) area within the fibroglandular tissue of the breast

An abscess is a localized collection of pus (purulent inflammatory tissue) caused by suppuration buried in a tissue, an organ, or a confined space, lined by the pyogenic membrane.[26] Ultrasound imaging can help in a diagnosis.[27]

Classification

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Abscesses may be classified as either skin abscesses or internal abscesses. Skin abscesses are common; internal abscesses tend to be harder to diagnose, and more serious.[13] Skin abscesses are also called cutaneous or subcutaneous abscesses.[28]

IV drug use

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For those with a history of intravenous drug use, an X-ray is recommended before treatment to verify that no needle fragments are present.[18] If there is also a fever present in this population, infectious endocarditis should be considered.[18]

Differential

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Abscesses should be differentiated from empyemas, which are accumulations of pus in a preexisting, rather than a newly formed, anatomical cavity.[29]

Other conditions that can cause similar symptoms include: cellulitis, a sebaceous cyst, and necrotising fasciitis.[3] Cellulitis typically also has an erythematous reaction, but does not confer any purulent drainage.[22]

Treatment

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The standard treatment for an uncomplicated skin or soft tissue abscess is the act of opening and draining.[4] There does not appear to be any benefit from also using antibiotics in most cases.[1] A small amount of evidence did not find a benefit from packing the abscess with gauze.[1]

Incision and drainage

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See also: Incision and drainage
Abscess five days after incision and drainage
Abscess following curettage

The abscess should be inspected to identify if foreign objects are a cause, which may require their removal. If foreign objects are not the cause, incising and draining the abscess is standard treatment.[4][30]

Antibiotics

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Most people who have an uncomplicated skin abscess should not use antibiotics.[4] Antibiotics in addition to standard incision and drainage is recommended in persons with severe abscesses, many sites of infection, rapid disease progression, the presence of cellulitis, symptoms indicating bacterial illness throughout the body, or a health condition causing immunosuppression.[1] People who are very young or very old may also need antibiotics.[1] If the abscess does not heal only with incision and drainage, or if the abscess is in a place that is difficult to drain such as the face, hands, or genitals, then antibiotics may be indicated.[1]

In those cases of abscess which do require antibiotic treatment, Staphylococcus aureus bacteria is a common cause and an anti-staphylococcus antibiotic such as flucloxacillin or dicloxacillin is used. The Infectious Diseases Society of America advises that the draining of an abscess is not enough to address community-acquired methicillin-resistant Staphylococcus aureus (MRSA), and in those cases, traditional antibiotics may be ineffective.[1] Alternative antibiotics effective against community-acquired MRSA often include clindamycin, doxycycline, minocycline, and trimethoprim-sulfamethoxazole.[1] The American College of Emergency Physicians advises that typical cases of abscess from MRSA get no benefit from having antibiotic treatment in addition to the standard treatment.[4]

Culturing the wound is not needed if standard follow-up care can be provided after the incision and drainage.[4] Performing a wound culture is unnecessary because it rarely gives information which can be used to guide treatment.[4]

Packing

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In North America, after drainage, an abscess cavity is usually packed, often with special iodoform-treated cloth. This is done to absorb and neutralize any remaining exudate as well as to promote draining and prevent premature closure. Prolonged draining is thought to promote healing. The hypothesis is that though the heart's pumping action can deliver immune and regenerative cells to the edge of an injury, an abscess is by definition a void in which no blood vessels are present. Packing is thought to provide a wicking action that continuously draws beneficial factors and cells from the body into the void that must be healed. Discharge is then absorbed by cutaneous bandages and further wicking promoted by changing these bandages regularly. However, evidence from emergency medicine literature reports that packing wounds after draining, especially smaller wounds, causes pain to the person and does not decrease the rate of recurrence, nor bring faster healing, or fewer physician visits.[31]

Loop drainage

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More recently, several North American hospitals have opted for less-invasive loop drainage over standard drainage and wound packing. In one study of 143 pediatric outcomes, a failure rate of 1.4% was reported in the loop group versus 10.5% in the packing group (P<.030),[32] while a separate study reported a 5.5% failure rate among the loop group.[33]

Primary closure

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Closing an abscess immediately after draining it appears to speed healing without increasing the risk of recurrence.[10] This may not apply to anorectal abscesses as while they may heal faster, there may be a higher rate of recurrence than those left open.[34]

Appendiceal abscess

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Appendiceal abscess are complications of appendicitis where there is an infected mass on the appendix. This condition is estimated to occur in 2–10% of appendicitis cases and is usually treated by surgical removal of the appendix (appendicectomy).[35]

Prognosis

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Even without treatment, skin abscesses rarely result in death, as they will naturally break through the skin.[3] Other types of abscess are more dangerous. Brain abscesses may be fatal if untreated. When treated, the mortality rate reduces to 5–10%, but is higher if the abscess ruptures.[36]

Epidemiology

[edit]

Skin abscesses are common and have become more common in recent years.[1] Risk factors include intravenous drug use, with rates reported as high as 65% among users.[2] In 2005, in the United States 3.2 million people went to the emergency department for an abscess.[5] In Australia around 13,000 people were hospitalized in 2008 for the disease.[11]

Society and culture

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The Latin medical aphorism "ubi pus, ibi evacua" expresses "where there is pus, there evacuate it" and is classical advice in the culture of Western medicine.[37]

Needle exchange programmes often administer or provide referrals for abscess treatment to injection drug users as part of a harm reduction public health strategy.[38][39]

Etymology

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An abscess is so called "abscess" because there is an abscessus (a going away or departure) of portions of the animal tissue from each other to make room for the suppurated matter lodged between them.[40]

The word carbuncle is believed to have originated from the Latin: carbunculus, originally a small coal; diminutive of carbon-, carbo: charcoal or ember, but also a carbuncle stone, "precious stones of a red or fiery colour", usually garnets.[41]

Other types

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The following types of abscess are listed in the medical dictionary:[42]

References

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  1. ^ a b c d e f g h i j k l m n o p q r s t Singer AJ, Talan DA (March 2014). "Management of skin abscesses in the era of methicillin-resistant Staphylococcus aureus" (PDF). The New England Journal of Medicine. 370 (11): 1039–1047. doi:10.1056/NEJMra1212788. PMID 24620867. Archived from the original (PDF) on 2014-10-30. Retrieved 2014-09-24.
  2. ^ a b c Ruiz P, Strain EC, Langrod J (2007). The substance abuse handbook. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. p. 373. ISBN 978-0-7817-6045-4. Archived from the original on 2017-09-06.
  3. ^ a b c d e f g h Marx JA (2014). "Skin and Soft Tissue Infections". Rosen's emergency medicine : concepts and clinical practice (8th ed.). Philadelphia, PA: Elsevier/Saunders. pp. Chapter 137. ISBN 978-1-4557-0605-1.
  4. ^ a b c d e f g h American College of Emergency Physicians, "Five Things Physicians and Patients Should Question", Choosing Wisely: an initiative of the ABIM Foundation, American College of Emergency Physicians, archived from the original on March 7, 2014, retrieved January 24, 2014
  5. ^ a b c Taira BR, Singer AJ, Thode HC, Lee CC (March 2009). "National epidemiology of cutaneous abscesses: 1996 to 2005". The American Journal of Emergency Medicine. 27 (3): 289–292. doi:10.1016/j.ajem.2008.02.027. PMID 19328372.
  6. ^ a b Elston DM (2009). Infectious Diseases of the Skin. London: Manson Pub. p. 12. ISBN 978-1-84076-514-4. Archived from the original on 2017-09-06.
  7. ^ Marx JA (2014). "Dermatologic Presentations". Rosen's emergency medicine : concepts and clinical practice (8th ed.). Philadelphia, PA: Elsevier/Saunders. pp. Chapter 120. ISBN 978-1-900151-96-2.
  8. ^ Cox C, Turkington JS, Birck D (2007). The encyclopedia of skin and skin disorders (3rd ed.). New York, NY: Facts on File. p. 1. ISBN 978-0-8160-7509-6. Archived from the original on 2017-09-06.
  9. ^ Vermandere M, Aertgeerts B, Agoritsas T, Liu C, Burgers J, Merglen A, et al. (February 2018). "Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline". BMJ. 360: k243. doi:10.1136/bmj.k243. PMC 5799894. PMID 29437651.
  10. ^ a b Singer AJ, Thode HC, Chale S, Taira BR, Lee C (May 2011). "Primary closure of cutaneous abscesses: a systematic review" (PDF). The American Journal of Emergency Medicine. 29 (4): 361–366. doi:10.1016/j.ajem.2009.10.004. PMID 20825801. Archived from the original (PDF) on 2015-07-22.
  11. ^ a b Vaska VL, Nimmo GR, Jones M, Grimwood K, Paterson DL (January 2012). "Increases in Australian cutaneous abscess hospitalisations: 1999-2008". European Journal of Clinical Microbiology & Infectious Diseases. 31 (1): 93–96. doi:10.1007/s10096-011-1281-3. PMID 21553298. S2CID 20376537.
  12. ^ "Skin abscess: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 2023-07-19.
  13. ^ a b "Abscess". United Kingdom National Health Service. Archived from the original on 2014-10-30.
  14. ^ Churchill Livingstone medical dictionary (16th ed.). Edinburgh: Churchill Livingstone. 2008. ISBN 978-0-08-098245-8.
  15. ^ a b "Intra-Abdominal Abscesses - Intra-Abdominal Abscesses". Merck Manual Professional Edition. Retrieved 2024-11-22.
  16. ^ Ferri FF (2014). Ferri's Clinical Advisor 2015 E-Book: 5 Books in 1. Elsevier Health Sciences. p. 20. ISBN 978-0-323-08430-7.
  17. ^ Fischer JE, Bland KI, Callery MP (2006). Mastery of Surgery. Lippincott Williams & Wilkins. p. 1033. ISBN 978-0-7817-7165-8.
  18. ^ a b c Khalil PN, Huber-Wagner S, Altheim S, Bürklein D, Siebeck M, Hallfeldt K, et al. (September 2008). "Diagnostic and treatment options for skin and soft tissue abscesses in injecting drug users with consideration of the natural history and concomitant risk factors". European Journal of Medical Research. 13 (9): 415–424. PMID 18948233.
  19. ^ a b Kraeutler MJ, Bozzay JD, Walker MP, John K (January 2015). "Spinal subdural abscess following epidural steroid injection". Journal of Neurosurgery. Spine. 22 (1): 90–93. doi:10.3171/2014.9.SPINE14159. PMID 25343407.
  20. ^ Oldendorf D (1999). The Gale Encyclopedia of Medicine. Detroit, MI: Gale Research. ISBN 978-0-7876-1868-1.
  21. ^ Sigmon DF, Emmanuel B, Tuma F (2023-06-12). "Perianal Abscess". StatPearls Publishing. PMID 29083652. Retrieved 2024-07-28.
  22. ^ a b c Duff P (2009). "Diagnosis and Management of Postoperative Infection". The Global Library of Women's Medicine. doi:10.3843/GLOWM.10032. ISSN 1756-2228. Archived from the original on 2014-07-14.
  23. ^ "abscess". www.vetneuro.com. Retrieved 2023-07-12.
  24. ^ a b c "A Brief Study on Abscess: A Review". EAS Journal of Pharmacy and Pharmacology. 3 (5).
  25. ^ "UOTW#66 – Ultrasound of the Week". Ultrasound of the Week. 7 January 2016. Archived from the original on 2 November 2016. Retrieved 27 May 2017.
  26. ^ Robins/8th/68
  27. ^ Barbic D, Chenkin J, Cho DD, Jelic T, Scheuermeyer FX (January 2017). "In patients presenting to the emergency department with skin and soft tissue infections what is the diagnostic accuracy of point-of-care ultrasonography for the diagnosis of abscess compared to the current standard of care? A systematic review and meta-analysis". BMJ Open. 7 (1): e013688. doi:10.1136/bmjopen-2016-013688. PMC 5253602. PMID 28073795.
  28. ^ "Abscess". Medline Plus. Archived from the original on 2016-04-07.
  29. ^ Gaillard F. "Abscess | Radiology Reference Article | Radiopaedia.org". Radiopaedia. doi:10.53347/rid-6723. Retrieved 2024-06-20.
  30. ^ Green J, Wajed S (2000). Surgery: Facts and Figures. Cambridge University Press. ISBN 978-1-900151-96-2.
  31. ^ Bergstrom KG (January 2014). "News, views, and reviews. Less may be more for MRSA: the latest on antibiotics, the utility of packing an abscess, and decolonization strategies". Journal of Drugs in Dermatology. 13 (1): 89–92. PMID 24385125.
  32. ^ Ladde JG, Baker S, Rodgers CN, Papa L (February 2015). "The LOOP technique: a novel incision and drainage technique in the treatment of skin abscesses in a pediatric ED". The American Journal of Emergency Medicine. 33 (2): 271–276. doi:10.1016/j.ajem.2014.10.014. PMID 25435407.
  33. ^ Tsoraides SS, Pearl RH, Stanfill AB, Wallace LJ, Vegunta RK (March 2010). "Incision and loop drainage: a minimally invasive technique for subcutaneous abscess management in children". Journal of Pediatric Surgery. 45 (3): 606–609. doi:10.1016/j.jpedsurg.2009.06.013. PMID 20223328.
  34. ^ Kronborg O, Olsen H (1984). "Incision and drainage v. incision, curettage and suture under antibiotic cover in anorectal abscess. A randomized study with 3-year follow-up". Acta Chirurgica Scandinavica. 150 (8): 689–692. PMID 6397949.
  35. ^ Cheng Y, Xiong X, Lu J, Wu S, Zhou R, Cheng N (2017-06-02). "Early versus delayed appendicectomy for appendiceal phlegmon or abscess". The Cochrane Database of Systematic Reviews. 6 (6): CD011670. doi:10.1002/14651858.CD011670.pub2. ISSN 1469-493X. PMC 6481778. PMID 28574593.
  36. ^ Bokhari MR, Mesfin FB (2019). "Brain Abscess". StatPearls. StatPearls Publishing. PMID 28722871. Retrieved 2019-07-28.
  37. ^ Mourits MP (2023), Gooris PJ, Mourits MP, Bergsma J (eds.), "Orbital Cellulitis", Surgery in and around the Orbit: CrossRoads, Cham: Springer International Publishing, pp. 309–315, doi:10.1007/978-3-031-40697-3_19, ISBN 978-3-031-40697-3
  38. ^ Tomolillo CM, Crothers LJ, Aberson CL (2007). "The damage done: a study of injection drug use, injection related abscesses and needle exchange regulation". Substance Use & Misuse. 42 (10): 1603–1611. doi:10.1080/10826080701204763. PMID 17918030. S2CID 20795955.
  39. ^ Fink DS, Lindsay SP, Slymen DJ, Kral AH, Bluthenthal RN (May 2013). "Abscess and self-treatment among injection drug users at four California syringe exchanges and their surrounding communities". Substance Use & Misuse. 48 (7): 523–531. doi:10.3109/10826084.2013.787094. PMC 4334130. PMID 23581506.
  40. ^ Collier's New Encyclopedia, 'Abscess'.
  41. ^ OED, "Carbuncle": 1 stone, 3 medical
  42. ^ "Abscess". Medical Dictionary – Dictionary of Medicine and Human Biology. Archived from the original on 2013-02-05. Retrieved 2013-01-24.
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